FOLTZ LAB

Publications

2024

  • Cytokines drive the formation of memory-like NK cell subsets via epigenetic rewiring and transcriptional regulation
    Foltz, J. A., Tran J, Wong P, Fan C, Schmidt E, Fisk B, Becker-Hapak M, Russler-Germain DA, Johnson J, Marin ND, Cubitt CC, Pence P, Rueve J, Pureti S, Hwang K, Gao F, Zhou AY, Foster M, Schappe T, Marsala L, Berrien-Elliott MM, Cashen AF, Bednarski JJ, Fertig E, Griffith OL, Griffith M, Wang T, Petti AA, Fehniger TA.
    Jun 2024, Science Immunology, 9(96), eadk4893. DOI | PMID: 38941480
  • Induced CD8α identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation
    Cubitt, C. C., Wong, P., Dorando, H. K., Foltz, J. A., Tran, J., Marsala, L., Marin, N. D., Foster, M., Schappe, T., Fatima, H., Becker-Hapak, M., Zhou, A. Y., Hwang, K., Jacobs, M. T., Russler-Germain, D. A., Mace, E. M., Berrien-Elliott, M. M., Payton, J. E., & Fehniger, T. A.,
    May 2024, Journal of Clinical Investigation, e173602. DOI | PMID: 38805302
  • A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma
    Pilcher WC, Yao L, Gonzalez-Kozlova E, Pita-Juarez Y, Karagkouni D, Acharya CR, Michaud ME, Hamilton M, Nanda S, Song Y, Sato K, Wang JT, Satpathy S, Ma Y, Schulman J, D'Souza D, Jayasinghe RG, Cheloni G, Bakhtiari M, Pabustan N, Nie K, Foltz, J. A., Saldarriaga I, Alaaeldin R, Lepisto E, Chen R, Fiala MA, Thomas BE, Cook A, Dos Santos JV, Chiang IL, Figueiredo I, Fortier J, Slade M, Oh ST, Rettig MP, Anderson E, Li Y, Dasari S, Strausbauch MA, Simon VA; Immune Atlas Consortium; Rahman AH, Chen Z, Lagana A, DiPersio JF, Rosenblatt J, Kim-Schulze S, Dhodapkar MV, Lonial S, Kumar S, Bhasin SS, Kourelis T, Vij R, Avigan D, Cho HJ, Mulligan G, Ding L, Gnjatic S, Vlachos IS, Bhasin M.
    May 2024, bioRxiv [Preprint], 2024.05.15.593193. DOI | PMID: 38798338
  • Memory-like differentiation enhances NK cell responses against colorectal cancer
    Marin ND, Becker-Hapak M, Song WM, Alayo QA, Marsala L, Sonnek N, Berrien-Elliott MM, Foster M, Foltz, J. A., Tran J, Wong P, Cubitt CC, Pence P, Hwang K, Zhou AY, Jacobs MT, Schappe T, Russler-Germain DA, Fields RC, Ciorba MA, Fehniger TA.
    May 2024, OncoImmunology, 13(1), 2348254. DOI | PMID: 38737793
  • Single-cell T-cell receptor repertoire profiling in dogs
    Hoang, M. H., Skidmore, Z. L., Rindt, H., Chu, S., Fisk, B., Foltz, J. A., Fronick, C., Fulton, R., Zhou, M., Bivens, N. J., Reinero, C. N., Fehniger, T. A., Griffith, M., Bryan, J. N. & Griffith, O. L.
    April 2024, Communications Biology, 7(1), 484. DOI | PMID: 38649520

2023

  • Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
    Gomez F, Fisk B, McMichael JF, Mosior M, Foltz, J. A., Skidmore ZL, Duncavage EJ, Miller CA, Abel H, Li YS, Russler-Germain DA, Krysiak K, Watkins MP, Ramirez CA, Schmidt A, Martins Rodrigues F, Trani L, Khanna A, Wagner JA, Fulton RS, Fronick CC, O'Laughlin MD, Schappe T, Cashen AF, Mehta-Shah N, Kahl BS, Walker J, Bartlett NL, Griffith M, Fehniger TA, Griffith OL.
    Nov 2023, Cancer research communications, 3(11), p. 2312-2330. DOI | PMID: 37910143
  • Memory-like Differentiation, Tumor-Targeting mAbs, and Chimeric Antigen Receptors Enhance Natural Killer Cell Responses to Head and Neck Cancer
    Jacobs MT, Wong P, Zhou AY, Becker-Hapak M, Marin ND, Marsala L, Foster M, Foltz, J. A., Cubitt CC, Tran J, Russler-Germain DA, Neal C, Kersting-Schadek S, Chang L, Schappe T, Pence P, McClain E, Zevallos JP, Rich JT, Paniello RC, Jackson RS, Pipkorn P, Adkins DR, DeSelm CJ, Berrien-Elliott MM, Puram SV, Fehniger TA.
    Oct 2023, Clinical Cancer Research, 29(20), p. 4196-4208. DOI | PMID: 37556118
  • T-BET and EOMES sustain mature human NK cell identity and antitumor function
    Wong P, Foltz, J. A., Chang L, Neal CC, Yao T, Cubitt CC, Tran J, Kersting-Schadek S, Palakurty S, Jaeger N, Russler-Germain DA, Marin ND, Gang M, Wagner JA, Zhou AY, Jacobs MT, Foster M, Schappe T, Marsala L, McClain E, Pence P, Becker-Hapak M, Fisk B, Petti AA, Griffith OL, Griffith M, Berrien-Elliott MM, Fehniger TA.
    Jul 2023, Journal of Clinical Investigation, 133(13), e162530. DOI | PMID: 37279078
  • Immunotherapeutic approach to reduce senescent cells and alleviate senescence-associated secretory phenotype in mice
    Shrestha N, Chaturvedi P, Zhu X, Dee MJ, George V, Janney C, Egan JO, Liu B, Foster M, Marsala L, Wong P, Cubitt CC, Foltz, J. A., Tran J, Schappe T, Hsiao K, Leclerc GM, You L, Echeverri C, Spanoudis C, Carvalho A, Kanakaraj L, Gilkes C, Encalada N, Kong L, Wang M, Fang B, Wang Z, Jiao JA, Muniz GJ, Jeng EK, Valdivieso N, Li L, Deth R, Berrien-Elliott MM, Fehniger TA, Rhode PR, Wong HC.
    May 2023, Aging Cell, 22(5), e13806. DOI | PMID: 36967480

2022

  • Role of NK-Like CD8+ T Cells during Asymptomatic Borrelia burgdorferi Infection
    Scorza, B. M., Mahachi, K. G., Cox, A. D., Toepp, A. J., Pessoa-Pereira, D., Tyrrell, P., Buch, J., Foltz, J. A., Lee, D. & Petersen, C. A.,
    May 2022, Infection and Immunity, 90, 5. DOI | PMID: 35416707
  • A novel fusion protein scaffold 18/12/TxM activates the IL-12, IL-15, and IL-18 receptors to induce human memory-like natural killer cells
    Cubitt, C. C., McClain, E., Becker-Hapak, M., Foltz, J. A., Wong, P., Wagner, J. A., Neal, C. C., Marin, N. D., Marsala, L., Foster, M., Schappe, T., Soon-Shiong, P., Lee, J., Berrien-Elliott, M. M. & Fehniger, T. A.,
    Mar 2022, Molecular Therapy - Oncolytics, 24, p. 585-596 12 p. DOI | PMID: 35284622
  • Donor memory-like NK cells persist and induce remissions in pediatric patients with relapsed AML after transplant
    Bednarski JJ, Zimmerman C, Berrien-Elliott MM, Foltz, J. A., Becker-Hapak M, Neal CC, Foster M, Schappe T, McClain E, Pence PP, Desai S, Kersting-Schadek S, Wong P, Russler-Germain DA, Fisk B, Lie WR, Eisele J, Hyde S, Bhatt ST, Griffith OL, Griffith M, Petti AA, Cashen AF, Fehniger TA.
    Mar 2022, Blood, 139, 11, p. 1670-1683 14 p. DOI | PMID: 34871371
  • Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia
    Berrien-Elliott MM, Foltz, J. A., Russler-Germain DA, Neal CC, Tran J, Gang M, Wong P, Fisk B, Cubitt CC, Marin ND, Zhou AY, Jacobs MT, Foster M, Schappe T, McClain E, Kersting-Schadek S, Desai S, Pence P, Becker-Hapak M, Eisele J, Mosior M, Marsala L, Griffith OL, Griffith M, Khan SM, Spencer DH, DiPersio JF, Romee R, Uy GL, Abboud CN, Ghobadi A, Westervelt P, Stockerl-Goldstein K, Schroeder MA, Wan F, Lie WR, Soon-Shiong P, Petti AA, Cashen AF, Fehniger TA.
    Feb 2022, Science Translational Medicine, 14, 633, abm1375. DOI | PMID: 35196021

2021

  • Defining the AHR-regulated transcriptome in NK cells reveals gene expression programs relevant to development and function
    Trikha, P., Moseman, J. E., Thakkar, A., Campbell, A. R., Elmas, E., Foltz, J. A., Chakravarti, N., Fitch, J. R., Mardis, E. R. & Lee, D. A.,
    Nov 2021, Blood Advances, 5, 22, p. 4605-4618 14 p. DOI | PMID: 34559190
  • Memory-like differentiation enhances NK cell responses to melanoma
    Marin, N. D., Krasnick, B. A., Becker-Hapak, M., Conant, L., Goedegebuure, S. P., Berrien-Elliott, M. M., Robbins, K. J., Foltz, J. A., Foster, M., Wong, P., Cubitt, C. C., Tran, J., Wetzel, C. B., Jacobs, M., Zhou, A. Y., Russler-Germain, D., Marsala, L., Schappe, T., Fields, R. C. & Fehniger, T. A.,
    Sep 2021, Clinical Cancer Research, 27, 17, p. 4859-4869 11 p. DOI | PMID: 34187852
  • Phase I trial of N-803, an IL15 receptor agonist, with rituximab in patients with indolent non-hodgkin lymphoma
    Foltz, J. A., Hess BT, Bachanova V, Bartlett NL, Berrien-Elliott MM, McClain E, Becker-Hapak M, Foster M, Schappe T, Kahl B, Mehta-Shah N, Cashen AF, Marin ND, McDaniels K, Moreno C, Mosior M, Gao F, Griffith OL, Griffith M, Wagner JA, Epperla N, Rock AD, Lee J, Petti AA, Soon-Shiong P, Fehniger TA.
    Jun 2021, Clinical Cancer Research, 27, 12, p. 3339-3350 12 p. DOI | PMID: 33832946

2020

  • Multidimensional analyses of donor memory-like NK cells reveal new associations with response after adoptive immunotherapy for leukemia
    Berrien-Elliott MM, Cashen AF, Cubitt CC, Neal CC, Wong P, Wagner JA, Foster M, Schappe T, Desai S, McClain E, Becker-Hapak M, Foltz, J. A., Cooper ML, Jaeger N, Srivatsan SN, Gao F, Romee R, Abboud CN, Uy GL, Westervelt P, Jacoby MA, Pusic I, Stockerl-Goldstein KE, Schroeder MA, DiPersio J, Fehniger TA.
    Dec 2020, Cancer Discovery, 10, 12, p. 1854-1872 19 p. DOI | PMID: 32826231
  • Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity
    Wagner, J. A., Wong, P., Schappe, T., Berrien-Elliott, M. M., Cubitt, C., Jaeger, N., Lee, M., Keppel, C. R., Marin, N. D., Foltz, J. A., Marsala, L., Neal, C. C., Sullivan, R. P., Schneider, S. E., Keppel, M. P., Saucier, N., Cooper, M. A., & Fehniger, T. A.,
    Jun 2020, Cell Reports, 31(9), 107720.
    DOI | PMID: 32492428
  • Evaluation of serum-free media formulations in feeder cell–stimulated expansion of natural killer cells
    Moseman, J. E., Foltz, J. A., Sorathia, K., Heipertz, E. L. & Lee, D. A.,
    Jun 2020, Cytotherapy, 22, 6, p. 322-328 7 p. DOI | PMID: 32278551
  • Blood and tissue biomarker analysis in dogs with osteosarcoma treated with palliative radiation and intra-tumoral autologous natural killer cell transfer
    Judge, S. J., Yanagisawa, M., Sturgill, I. R., Bateni, S. B., Gingrich, A. A., Foltz, J. A., Lee, D. A., Modiano, J. F., Monjazeb, A. M., Culp, W. T. N., Rebhun, R. B., Murphy, W. J., Kent, M. S. & Canter, R. J.,
    Feb 2020, PloS one, 15, 2, e0224775. DOI | PMID: 32084139

2019

  • Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells
    Schafer, J. R., Salzillo, T. C., Chakravarti, N., Kararoudi, M. N., Trikha, P., Foltz, J. A., Wang, R., Li, S. & Lee, D. A.,
    Jan 2019, Journal of Allergy and Clinical Immunology, 143, 1, p. 346-358.e6. DOI | PMID: 30096390

2018

  • Tgfβ imprinting during activation promotes natural killer cell cytokine hypersecretion
    Foltz, J. A., Moseman, J. E., Thakkar, A., Chakravarti, N. & Lee, D. A.,
    Nov 2018, Cancers, 10, 11, 423. DOI | PMID: 30400618
  • Generation of knock-out primary and expanded human NK cells using Cas9 ribonucleoproteins
    Kararoudi, M. N., Dolatshad, H., Trikha, P., Hussain, S. R. A., Elmas, E., Foltz, J. A., Moseman, J. E., Thakkar, A., Nakkula, R. J., Lamb, M., Chakravarti, N., McLaughlin, K. J. & Lee, D. A.,
    Jun 2018, Journal of Visualized Experiments, 2018, 136, e58237. DOI | PMID: 29985369
  • Natural Killer Cell-Based Immunotherapy
    Foltz, J. A., Miller, J. S. & Lee, D. A.,
    Apr 2018, Immunotherapy in Translational Cancer Research. Wiley Blackwell, p. 215-227 13 p. DOI

2017

  • Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial
    Canter, R. J., Grossenbacher, S. K., Foltz, J. A., Sturgill, I. R., Park, J. S., Luna, J. I., Kent, M. S., Culp, W. T. N., Chen, M., Modiano, J. F., Monjazeb, A. M., Lee, D. A. & Murphy, W. J.,
    Dec 2017, Journal for ImmunoTherapy of Cancer, 5, 1, 98. DOI | PMID: 29254507

2016

  • NCR1 expression identifies canine natural killer cell subsets with phenotypic similarity to human natural killer cells
    Foltz, J. A., Somanchi, S. S., Yang, Y., Aquino-Lopez, A., Bishop, E. E. & Lee, D. A.,
    Nov 2016, Frontiers in Immunology, 7, NOV, 521. DOI | PMID: 27933061